Impact of Pongamia Pinnata extract on lead acetate mediated toxicity in rat liver

The hepato protective effect of the methanolic extract of Pongamia Pinnata flowers, an indigenous. Ayurvedic medicinal plant in India, was studied in rats with lead acetate induced hepatotoxicity. Administering 160 mg/kg b.wt/day of lead acetate for 90 days to male albino rats resulted in significantly elevated levels of ALT, AST, GGT, ALP, Bilirubin and protein were also observed on lead acetate administration as compared with those of the experimental control rats. Methanolic Pongamia Pinnata flowers was administered at a dose of 150 mg/kg b.wt / day for the 90 days of experiment to lats with lead acetate induced liver injury, which significantly decreased the levels of ALT, AST, ALP, GGT, Bilisubin and protein compared to that untreated lead acetate administered rats. Thus, the data indicate that treatment with methanolic Pongamia Pinnata flowers against toxicity in liver of animals with lead acetate induced liver injury.